The Health Department says measures will be in place to monitor people for possible side-effects after receiving the COVID-19 vaccine.
The government wants to vaccinate over 40 million South Africans by the end of the year in a bid to achieve herd immunity against the virus.
The first one million doses of the vaccines are expected to arrive in the country before the end of the month.
Speaking during a webinar organised by the African National Congress Progressive Business Forum, a member of the COVID-19 Partnership Task Team, Dr Aquina Thulare says health professionals will be on site to deal with any eventuality during the vaccination process.
Some South Africans, among them health care workers, have mixed feelings about a COVID-19 vaccine.
They say conflicting messages on social media, especially about the side effects of the vaccine, make them skeptical about its efficacy.